NCBI Bookshelf. Kamel ; Sebastiano Cassaro. Kamel 3 ; Sebastiano Cassaro 4. Perforation of the stomach is a full-thickness injury of the wall of the organ. Since peritoneum completely covers the stomach, perforation of the wall creates a communication between the gastric lumen and the peritoneal cavity. If the perforation occurs acutely, there is no time for an inflammatory reaction to wall off the perforation, and the gastric content is free to enter the general peritoneal cavity, causing chemical peritonitis.
Peptic ulcer disease - Wikipedia
Richard Patterson is a retired surgeon and chief medical officer with special interest and experience in gastrointestinal, breast, cancer and trauma surgery. He is the author or co-author of 17 scientific publications, including textbook chapters. Peptic ulcers are erosions of the tissues lining the upper digestive tract, particularly the stomach and first portion of the small intestine, the duodenum. They are often caused by a bacterial infection that compromises your defense against the acid produced in the stomach. Peptic ulcers sometimes penetrate completely through the stomach or intestinal wall, resulting in a hole -- or perforation -- and spillage of acid, digestive enzymes and partially digested food into the abdominal cavity. Several signs and symptoms typically result, although they can occur with conditions other than a perforated ulcer.
Diagnosis and treatment of perforated or bleeding peptic ulcers: 2013 WSES position paper
Every year peptic ulcer disease PUD affects 4 milion people around the world [ 1 ]. More than half of the cases are female and they are usually older and have more comorbidities than their male counterparts [ 6 ]. Main etiologic factors include use of non-steroidal anti-inflammatory drugs NSAIDs , steroids, smoking, Helicobacter pylori and a diet high in salt [ 3 , 7 ]. All these factors have in common that they affect acid secretion in the gastric mucosa. Defining the exact etiological factor in any given patient may often be difficult, as more than one risk factor may be present and they tend to interact [ 8 ].
Please take this quick survey to tell us about what happens after you publish a paper. Fatal complications of peptic ulcer disease usually involve either perforation or hemorrhage. The case of a year-old female is reported who was found dead at her home address. The autopsy revealed a perforated pyloroduodenal ulcer with localized abscess formation in the lesser sac behind the stomach and established peritonitis.